Analytic validity of genetic tests to identify factor V Leiden and prothrombin G20210A
نویسندگان
چکیده
منابع مشابه
Frequency of factor V Leiden (G1691A) and prothrombin (G20210A) polymorphisms in Population of Kerman Province, Iran
Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease. We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population.<br /...
متن کاملFactor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
متن کاملIncidence of Factor V Leiden and prothrombin G20210A in patients submitted to stem cell transplantation.
1. Richardson PG, Elias AD, Krishnan A, et al.Treatment of severe veno occlusive disease with defribotide: compassionate use results in efficacy without significant toxicity in high risk population. Blood 1997; 90(Suppl 1):252a. 2. Thung SN, Gerber MA, Bodenheimer HC Jr. Nodular regenerative hyperplasia of the liver in a patient with diabetes mellitus. Cancer 1982; 49:543-6. 3. Duvoux C, Kracht...
متن کاملFrequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran
Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...
متن کاملFactor V Leiden, prothrombin G20210A and MTHFR C677T mutations in Romanian patients with deep venous thrombosis
Introduction Deep venous thrombosis (DVT), with an incidence of about 1 case/year/1000 adults, is a multifactorial disease, result of the interaction between genetic and acquired risk factors. Although considered idiopathic in majority of the cases, an underlying cause could be detected in up to 80% of the patients with DVT, as shown in the literature (Whitlatch 2008). Genetic factors contribut...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2010
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21617